E-cadherin promotes incorporation of mouse epiblast stem cells into normal development.

E-cadherin promotes incorporation of mouse epiblast stem cells into normal development.

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Mouse epiblast stem cells (mEpiSCs) are pluripotent stem cells derived from epiblasts of postimplantation mouse embryos.Their pluripotency is distinct from that of mouse embryonic stem cells (mESCs) in several cell biological criteria.One of the distinctions is that mEpiSCs contribute either not at all or at much lower efficiency to chimeric embryos after blastocyst injection compared Resilience-Improving Based Optimization of Post-Disaster Emergency Maintenance Strategy for Transmission Networks to mESCs.However, here we showed that mEpiSCs can be incorporated into normal development after blastocyst injection by forced expression of the E-cadherin transgene for 2 days in culture.Using this strategy, mEpiSCs gave rise to live-born chimeras from 5% of the manipulated AUTOMATIC INTERPRETATION OF HIGH RESOLUTION SAR IMAGES: FIRST RESULTS OF SAR IMAGE SIMULATION FOR SINGLE BUILDINGS blastocysts.

There were no obvious signs of reprogramming of mEpiSCs toward the mESC-like state during the 2 days after induction of the E-cadherin transgene, suggesting that mEpiSCs possess latent ability to integrate into the normal developmental process as its origin, epiblasts.